Detroit (pronounce /dɪˈtrɔɪt/) (French: Détroit, meaning "strait", pronounced [detʁwa] (help·info)) is the largest city in the U.S. state of Michigan and the seat of Wayne County. Detroit is a major port city on the Detroit River, in the Midwest region of the United States. Located north of Windsor, Ontario, Detroit is the only major U.S. city that looks south to Canada. It was founded in 1701 by the Frenchman Antoine de la Mothe Cadillac.