The Mantoux test (also known as the Mantoux screening test, Tuberculin Sensitivity Test, Pirquet test, or PPD test for Purifie Protein Derivative) is a diagnostic tool for tuberculosis. It is one of the two major tuberculin skin tests used in the world, largely replacing multiple-puncture tests such as the Tine test. Until 2005, the Heaf test was used in the United Kingdom, but the Mantoux test is now used. The Mantoux test is also used in Australia, Canada, Hungary, The Netherlands, Portugal, and the United States and is endorsed by the American Thoracic Society and Centers for Disease Control and Prevention (CDC). It was also used in the USSR and is now prevalent in most of the former Soviet states.