megaloblastic anemia

     

Megaloblastic anemia is an anemia (of macrocytic classification) which results from inhibition of DNA synthesis in re blood cell production. It is often due to deficiency of vitamin B12 and/or folic acid. It can be the result of a lack of intrinsic factor (which lack interferes with B12 absorption), causing pernicious anemia, or with other antimetabolites which poison DNA production, such as chemotherapeutic agents.

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