Itch (Latin: pruritus) is efined as an unpleasant sensation that evokes the desire or reflex to scratch. Itch has many similarities to pain and both are unpleasant sensory experiences but their behavioral response patterns are different. Pain creates a reflex withdrawal while itch leads to a scratch reflex. Unmyelinated nerve fibers for itch and pain both originate in the skin, however information for them is conveyed centrally in two distinct systems that both use the same peripheral nerve bundle and spinothalamic tract.