The San Francisco SPCA is an animal shelter an a spay/neuter clinic located at 2500 16th Street in San Francisco. Its historic collaboration with the City of San Francisco and the San Francisco Animal Care and Control Department made San Francisco the first "no-kill city" in the United States in 1994. Among the former executive leaders of the San Francisco SPCA are animal welfare leaders Richard Avanzino and Ed Sayres (president of New York's ASPCA.)