The event which many historians of science call the scientific revolution can be ated roughly as having begun in 1543, the year in which Nicolaus Copernicus published his De revolutionibus orbium coelestium (On the Revolutions of the Heavenly Spheres) and Andreas Vesalius published his De humani corporis fabrica (On the Fabric of the Human body). As with many historical demarcations, historians of science disagree about its boundaries. Although the period is commonly dated to the 16th and 17th centuries, some see elements contributing to the revolution as early as the middle ages, and finding its last stages in chemistry and biology in the 18th and 19th centuries. There is general agreement, however, that the intervening period saw a fundamental transformation in scientific ideas in physics, astronomy, and biology, in institutions supporting scientific investigation, and in the more widely held picture of the universe. As a result, the scientific revolution is commonly viewed as a foundation and origin of modern science. The "Continuity Thesis" is the opposing view that there was no radical discontinuity between the development of science in the Middle Ages and later developments in the Renaissance and early modern period.