Season six of Smallville, an American television series, began airing on September 28, 2006. The season conclued on May 17, 2007, after 22 episodes. This is the first season to air on the newly formed CW television network. Season six regular cast members include Tom Welling, Kristin Kreuk, Michael Rosenbaum, Erica Durance, Allison Mack, John Glover and Annette O'Toole.