In physiology, a smile is a facial expression forme by flexing those muscles most notably near both ends of the mouth. The smile can also be found around the eyes ("#Duchenne smile"; below). Among humans, it is customarily an expression denoting pleasure, happiness, or amusement, but can also be an involuntary expression of anxiety, in which case it can be known as a grimace. There is much evidence that smiling is a normal reaction to certain stimuli as it occurs regardless of culture. Happiness is most often the motivating cause of a smile. Among animals, the exposure of teeth, which may bear a resemblance to a smile, is often used as a threat or warning display - known as a snarl - or a sign of submission. In chimpanzees, it can also be a sign of fear.