State College, Pennsylvania, is the largest borough in Centre County in the U.S. state of Pennsylvania. It is the principal city of the State College, Pennsylvania Metropolitan Statistical Area which encompasses all of Centre county. As of the 2000 census, the borough population was 38,420, (estimate 38,720 in 2007) and roughly double that total lived in the borough plus the surrounding townships. Of that population, 20,011 or 52.1% are males and 18,409 or 47.9% are females.City Data.