Yakult (ヤクルト, Yakuruto) is a Japanese probiotic yogurt-like product made by fermenting a mixture of skimmed milk with a special strain of the bacteria Lactobacillus casei Shirota. Yakult Honsha Co., Ltd. (株式会社ヤクルト本社, Kabushiki-gaisha Yakuruto Honsha?) (TYO: 2267) It was created by Minoru Shirota who graduated from the Medical School of Kyoto University in 1930. In 1935, he started manufacturing and selling Yakult. Official claims state that the name is derived from jahurto, an older form of jogurto, the Esperanto word for "yogurt". Since then, Yakult has also introduced a line of beverages for the Japanese market that contain Bifidobacterium breve bacteria, and has also used its lactobacilli research to develop cosmetics. More recently, the Yakult Honsha played a major role in developing the chemotherapy drug irinotecan (Camptosar, CPT-11).